Donor Factors Affecting Short Term Graft Outcome in Live Donor Kidney Transplantation

  • Rabin Nepali
  • Dibya S Shah
  • Prem R Gyawali
  • Uttam Sharma
  • Pawan R Chalise

Abstract

Introduction
Since the beginning of renal transplant, the objective has been to increase the patient and graft survival, both
short term and long term. Data relating to donor factors affecting short term survival at 6 months in live donor
kidney transplantation has been scarce. This single center study tries to examine the predictors of short term
graft outcome at six months in recipients of live donor kidney transplants and explore which donor characteristics
are the most useful in predicting the post-transplant graft function in Nepalese population.
Methods
All patients who underwent kidney transplantation between May 2015 to July 2016 were included in the study.
The patients who expired during follow were excluded. The clinical and laboratory parameters of the donors were
recorded. The recipients were followed up for six months post transplantation. The eGFR of the recipients and the
occurrence of rejection were recorded at the end of six months post transplantation.
Results
A total of 82 donor-recipient pairs underwent living donor renal transplantation at our hospital during the study
period. One recipient who expired during follow up was excluded. The mean age of donor was 45.20 ± 11.226
years of which 55 (67.9%) were female and 26 (32.1 %) were male. The mean eGFR of the donor calculated
from Cockcroft Gault equation was 81.98 ± 18.11. The eGFR of the recipient at the end of six months post
transplantation calculated form the MDRD equation was 67.76 ± 20.94. A total of 7 patients (8.6%) had rejection
that were biopsy proven. Only donor eGFR was found to be significantly associated with eGFR of the recipient
at six months post transplantation (p=0.034). Body mass index of the donor was significantly associated with
rejection in the recipient at six months post transplantation (p=0.011).
Conclusion
Our study demonstrates that the donor eGFR and body mass index are independent and important factors
affecting the short term graft outcome at six months post transplantation.
Keywords
Body mass index, donor eGFR, graft outcome, renal transplantation

Published
2019-08-26